The author of 《The invention of radical reactions. Part XVIII. A convenient solution to the 1-carbon problem (R-CO2H → R-13CO2H)》 were Barton, Derek H. R.; Ozbalik, Nubar; Vacher, Bernard. And the article was published in Tetrahedron in 1988. Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide The author mentioned the following in the article:
Radicals generated by photolysis (W light) of esters derived from N-hydroxy-2-thiopyridone react with electrophilic isocyanides PhCH2CH2NC and (in the presence of CF3CO2H)Me(CH2)4NC to give adducts of type R1N:CRSC5H4N-2 (C5H4N-2 = 2-pyridyl). Convenient reaction procedures have been worked out to hydrolyze the adducts to amides of type RCONHR1, from which the original acid RCO2H can be regenerated under mild conditions. The three important acids oleic, linoleic and arachidonic have all given smooth reactions. In suitable examples, quant. evolution of CO2 and incorporation of 13C without dilution have been demonstrated. This reaction sequence will be useful for the labeling in the carboxyl group of prostaglandins, leukotrienes, and the side chain carboxyls of peptides. The experimental part of the paper was very detailed, including the reaction process of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide)
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics