In 2018,Yu, Chang-Bin; Wang, Jie; Zhou, Yong-Gui published 《Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles》.Organic Chemistry Frontiers published the findings.Name: N-Methoxy-N-methylacetamide The information in the text is summarized as follows:
A concise and enantioselective procedure for the synthesis of optically active indolines I [R = Me, n-Bu, Bn, etc.; R1 = H, 2-Me, 2-OMe, 4-OMe, 2,4-di-Me] was developed through intramol. condensation, deprotection and palladium-catalyzed asym. hydrogenation in a one-pot process with up to 96% ee. A strong Bronsted acid played an important role in both the formation of indoles and asym. hydrogenation process. This strategy could be scaled-up with excellent reactivity and enantioselectivity. The results came from multiple reactions, including the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1Name: N-Methoxy-N-methylacetamide)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Name: N-Methoxy-N-methylacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics