Yang, Xing’s team published research in Journal of Medicinal Chemistry in 2016 | CAS: 71432-55-8

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Product Details of 71432-55-8

In 2016,Yang, Xing; Mease, Ronnie C.; Pullambhatla, Mrudula; Lisok, Ala; Chen, Ying; Foss, Catherine A.; Wang, Yuchuan; Shallal, Hassan; Edelman, Hannah; Hoye, Adam T.; Attardo, Giorgio; Nimmagadda, Sridhar; Pomper, Martin G. published 《[18F]Fluorobenzoyllysinepentanedioic Acid Carbamates: New Scaffolds for Positron Emission Tomography (PET) Imaging of Prostate-Specific Membrane Antigen (PSMA)》.Journal of Medicinal Chemistry published the findings.Product Details of 71432-55-8 The information in the text is summarized as follows:

Radiolabeled urea-based low-mol. weight inhibitors of the prostate-specific membrane antigen (PSMA) are under intense investigation as imaging and therapeutic agents for prostate and other cancers. In an effort to provide agents with less nontarget organ uptake than the ureas, we synthesized four 18F-labeled inhibitors of PSMA based on carbamate scaffolds. 4-Bromo-2-[18F]fluorobenzoyllysineoxypentanedioic acid (OPA) carbamate and 4-iodo-2-[18F]fluorobenzoyllysine OPA carbamate (I) in particular exhibited high target-selective uptake in PSMA+ PC3 PIP tumor xenografts, with tumor-to-kidney ratios of >1 by 4 h postinjection, an important benchmark. Because of its high tumor uptake (90% injected dose per g of tissue at 2 h postinjection) and high tumor-to-organ ratios, I (X=Br) is promising for clin. translation. Prolonged tumor-specific uptake demonstrated by I (X=I), which did not reach equilibrium during the 4 h study period, suggests carbamates as alternative scaffolds for mitigating dose to nontarget tissues. The results came from multiple reactions, including the reaction of tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Product Details of 71432-55-8)

tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Product Details of 71432-55-8

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics