Yang, Kai; Ke, Miaolin; Lin, Yuanguang; Song, Qiuling published the artcile< Sulfonamide formation from sodium sulfinates and amines or ammonia under metal-free conditions at ambient temperature>, SDS of cas: 1524-40-9, the main research area is morpholine piperidine pyrrolidine sulfonamide analog preparation; sulfonamide preparation green chem.
A novel, practical and highly efficient method for the construction of a variety of sulfonamides mediated by iodine (I2) was demonstrated. The reaction proceeds readily at room temperature using a variety of sodium sulfinates (sulfinic acid salts) and amines or ammonia in water in a metal-free, base-free, ligand-free or additive-free protocol. Primary, secondary and tertiary sulfonamides were obtained in good to excellent yields with a broad range of functional group tolerability. The synthesis of the target compounds was achieved using benzenamine derivatives (aryl amines, aromatic amines), benzenemethanamine (benzyl amine, aralkyl amine), 1H-benzimidazole derivatives, 3-pyridinamine, N-ethylethanamine, pyrrolidine, piperidine, morpholine, 2-propyn-1-amine (propargyl amine), diallylamine, N,N’-dimethyl-1,2-ethanediamine, L-leucine Me ester hydrochloride, L-phenylalanine Me ester hydrochloride as starting materials. Sulfinic acid salts included benzenesulfinic acid sodium salt, 8-quinolinesulfinic acid sodium salt, cyclopropanesulfinic acid sodium salt, 2-naphthalenesulfinic acid sodium salt. The title compounds thus formed included benzenesulfonamide derivatives and analogs such as 1-(phenylsulfonyl)piperidine, 1-(phenylsulfonyl)morpholine, 1-(phenylsulfonyl)pyrrolidine, 1-(phenylsulfonyl)-1H-benzimidazole, 4-(2-naphthalenylsulfonyl)morpholine, 8-(4-morpholinylsulfonyl)quinoline. Amino acid derivatives included N-(phenylsulfonyl)-L-leucine Me ester and N-(phenylsulfonyl)-L-phenylalanine Me ester.
Green Chemistry published new progress about Allyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, SDS of cas: 1524-40-9.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics