Wu, Kui; Li, Yajun published the artcile< Solid-liquid phase equilibrium and solution thermodynamics of 2-chlorobenzenesulfonamide in 16 mono solvents at temperature ranging from 273.15 K to 324.65 K>, Application In Synthesis of 6961-82-6, the main research area is chlorobenzenesulfonamide solid liquid phase equilibrium solution thermodn.
The synthesis and separation processes of chem. intermediate is based on the knowledge of its solid-liquid phase equilibrium with solvents in industry. In this work, the solubility of 2-chlorobenzenesulfonamide in 16 single pure solvents including methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, acetone, 2-butanone, 2-pentanone, cyclohexanone, cyclopentanone, Et acetate, Me acetate, Et formate, acetonitrile and THF was determined at temperature range from 273.15 to 324.65 K and atm. pressure. The mole fraction solubility of 2-chlorobenzenesulfonamide in all selected mono solvents was enhanced by an increase in temperature In addition, the exptl. data were further correlated by the modified Apelblat equation, λh equation, NRTL model and Wilson model. The values of RAD with NRTL equation were smaller than those with other three models, and thus the NRTL model offered the best fitting performance. The thermodn. functions of dissolution including enthalpy, entropy, and Gibbs energy were derived, and the results expectedly suggested a spontaneous and entropy-driven mixing process. All the crystallog. and thermodn. data reported in this study provides the fundamental data for designing and optimizing of the reaction and crystallization processes of 2-chlorobenzenesulfonamide.
Journal of Molecular Liquids published new progress about Crystallization. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application In Synthesis of 6961-82-6.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics