Tang, Guozhi; Kertesz, Denis J.; Yang, Minmin; Lin, Xianfeng; Wang, Zhanguo; Li, Wentao; Qiu, Zongxing; Chen, Junli; Mei, Jianghua; Chen, Li; Mirzadegan, Taraneh; Harris, Seth F.; Villasenor, Armando G.; Fretland, Jennifer; Fitch, William L.; Hang, Julie Qi; Heilek, Gabrielle; Klumpp, Klaus published the artcile< Exploration of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses>, Category: amides-buliding-blocks, the main research area is piperidinylpyrimidinamine preparation HIV 1 reverse transcriptase inhibitor; pyrimidinamine piperidinyl preparation structure activity relationship antiviral.
Further investigation on the recently reported N-(piperidin-4-yl)pyrimidin-2-amines I (R = H, 4-Cl, 5-Cl, 6-Cl; R1 = H, 4-SO2NH2, 3-SO2NH2, 2-CONH2, 3-CONH2, 4-CONH2, 3-SO2Me, 3-CN, 3-CO2H; R2 = H, Br, Cl, F, Me, CF3, NH2, NO2; R3 = Me, Cl, OMe, F) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) was carried out. Thus, preparation of a series of N-phenylpiperidine analogs resulted in the identification of 3-carboxamides as a particularly active series. Two of the compounds were very potent vs. wild-type HIV-1 and a broad range of NNRTI-resistant mutant viruses. Synthesis (no data), structure-activity relationship (SAR), clearance data, and crystallog. evidence for the binding motif were discussed.
Bioorganic & Medicinal Chemistry Letters published new progress about AIDS (disease). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Category: amides-buliding-blocks.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics