Ogita, Haruhisa; Isobe, Yoshiaki; Takaku, Haruo; Sekine, Rena; Goto, Yuso; Misawa, Satoru; Hayashi, Hideya published the artcile< Synthesis and structure-activity relationship of diarylamide urea derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells>, Computed Properties of 5004-88-6, the main research area is diarylamide urea Tranilast analog preparation vascular cell proliferation.
A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound I was superior to the lead compound, Tranilast, in terms of its potency of inhibitory activity and cell selectivity.
Bioorganic & Medicinal Chemistry published new progress about Cell proliferation. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Computed Properties of 5004-88-6.
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