《Engaging Sulfonamides: Intramolecular Cross-Electrophile Coupling Reaction of Sulfonamides with Alkyl Chlorides》 was published in Journal of Organic Chemistry in 2020. These research results belong to Lucas, Erika L.; Hewitt, Kirsten A.; Chen, Pan-Pan; Castro, Anthony J.; Hong, Xin; Jarvo, Elizabeth R.. Recommanded Product: 4-Methylbenzenesulfonamide The article mentions the following:
The application of amine derivatives as coupling partners is rare due to the inherent strength of the C-N bond. Herein, the first cross-electrophile coupling reaction of unstrained benzylic sulfonamides is repoted. Nickel-catalyzed intramol. cross-electrophile coupling reactions of acyclic and cyclic benzylic sulfonamides with pendant alkyl chlorides generate cyclopropane products. Mechanistic experiments and DFT calculations are consistent with initiation of the reaction by magnesium iodide accelerated oxidative addition of the benzylic sulfonamide. This work establishes neutral and unstrained amine derivatives as XEC partners, furnishes structural rearrangement of benzylic sulfonamides, and provides valuable information regarding catalyst design for the development of new cross-electrophile coupling reactions of carbon-heteroatom bonds. The results came from multiple reactions, including the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 4-Methylbenzenesulfonamide)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Recommanded Product: 4-Methylbenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics