Hauser, Melanie R.; Zhakarov, Lev; Doxsee, Kenneth M.; Li, Tonglei published their research in Crystal Growth & Design on December 31 ,2008. The article was titled 《Polymorphism of a Simple Organic Amide》.Category: amides-buliding-blocks The article contains the following contents:
Glycolanilide (2-hydroxy-N-phenylacetamide), a simple amide, may be reproducibly crystallized in either of two polymorphic forms. The crystal and mol. structures of each polymorph have been determined, revealing that the two polymorphs differ in the extent and arrangement of intermol. hydrogen bonding. The more stable polymorph displays one-dimensional chains linked through hydrogen bonds between the amide carbonyl and the α-hydroxyl group. In the metastable polymorph, analogous chain structures are overlain with cyclic hydrogen-bonded amide dimers, with an addnl. set of hydrogen bonding contacts joining the chain and cyclic motifs. The experimental process involved the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Category: amides-buliding-blocks)
2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics