Guerra, Walter D.; Lucena-Agell, Daniel; Hortigueela, Rafael; Rossi, Roberto A.; Fernando Diaz, J.; Padron, Jose M.; Barolo, Silvia M. published the artcile< Design, Synthesis, and in vitro Evaluation of Tubulin-Targeting Dibenzothiazines with Antiproliferative Activity as a Novel Heterocycle Building Block>, Application In Synthesis of 6961-82-6, the main research area is dibenzothiazine preparation antiproliferative SAR cell cycle tubulin inhibitor human; Antiproliferation; dibenzothiazines; drug design; sulfonamides; tubulin inhibitors.
A series of free NH and N-substituted dibenzonthiazines I [R1 = H, F, CF3, Ph; R2 = H, 9-F, 7-Ph, etc.; R3 = H, Me, Bn, etc.] with potential anti-tumor activity from N-aryl-benzenesulfonamides was prepared A biol. test of synthesized compounds was performed in vitro measuring their antiproliferative activity against a panel of six human solid tumor cell lines and its tubulin inhibitory activity. Compounds I [R1 = R2 = H; R3 = SO2C6H5, 4-MeC6H4SO2] showed as the best compounds with promising values of activity (overall range of 2-5.4μM).
ChemMedChem published new progress about Antiproliferative agents. 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application In Synthesis of 6961-82-6.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics