In 1999,Journal of Molecular Modeling included an article by Wang, Jiansuo; Lai, Luhua; Tang, Youqi. HPLC of Formula: 4746-61-6. The article was titled 《Data mining of toxic chemicals: structure patterns and QSAR》. The information in the text is summarized as follows:
The authors take a two-step strategy to explore non-congeneric toxic chems. from the database RTECS: the screening of structure patterns and the generation of a detailed relationship between structure and activity. An efficient similarity comparison is proposed to screen chem. patterns for further QSAR anal. Then CoMFA study is carried out on one structure pattern as an example of the implementation, and the result shows that QSAR studies of structure patterns can provide an estimate of the activity as well as a detailed relationship between activity and structure. From the performance of overall procedure, such a stepwise scheme is demonstrated to be feasible and effective to mine a database of toxic chems.2-Hydroxy-N-phenylacetamide(cas: 4746-61-6HPLC of Formula: 4746-61-6) was used in this study.
2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.HPLC of Formula: 4746-61-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics