Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamideOn October 7, 1983 ,《Regiospecific electrophilic substitution of aminopyridines: ortho lithiation of 2-, 3-, and 4-(pivaloylamino)pyridines》 was published in Journal of Organic Chemistry. The article was written by Turner, James A.. The article contains the following contents:
2- And 4-(Pivaloylamino)pyridines undergo lithiation exclusively at C-3 and then react with a variety of electrophiles to produce 2,3- and 3,4-disubstituted pyridines, resp. Removal of the pivaloyl protecting group results in overall electrophilic substitution of an aminopyridine. Utilization of this method is exemplified by efficient syntheses of 2- and 4-aminonicotinaldehydes. Minor modifications of the reaction conditions permitted exclusive ortho lithiation of 2-(pivaloylamino)pyridines addnl. functionalized by chloro, fluoro, or Me groups. Although the major product from reaction of 3-(pivaloylamino)pyridine by this method was lithiation at C-4, the reaction was complicated by substantial quantities of product derived from nucleophilic attack by BuLi on the pyridine nucleus. In addition to this study using 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, there are many other studies that have used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide) was used in this study.
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Safety of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics