The author of 《NIPAm-Based Modification of Poly(L-lysine): A pH-Dependent LCST-Type Thermo-Responsive Biodegradable Polymer》 were Stamou, Aggeliki; Iatrou, Hermis; Tsitsilianis, Constantinos. And the article was published in Polymers (Basel, Switzerland) in 2022. Formula: C11H22N2O4 The author mentioned the following in the article:
Polylysine is a biocompatible, biodegradable, water soluble polypeptide. Thanks to the pendant primary amines it bears, it is susceptible to modification reactions. In this work Poly(L-lysine) (PLL) was partially modified via the effortless free-catalyzed aza-Michael addition reaction at room temperature by grafting N-isopropylacrylamide (NIPAm) moieties onto the amines. The resulting PLL-g-NIPAm exhibited LCST-type thermosensitivity. The LCST can be tuned by the NIPAm content incorporated in the macromols. Importantly, depending on the NIPAm content, LCST is highly dependent on pH and ionic strength due to ionization capability of the remaining free lysine residues. PLL-g-NIPAm constitutes a novel biodegradable LCST polymer that could be used as “”smart”” block in block copolymers and/or terpolymers, of any macromol. architecture, to design pH/Temperature-responsive self-assemblies (nanocarriers and/or networks) for potential bio-applications. In the part of experimental materials, we found many familiar compounds, such as H-Lys(Boc)-OH(cas: 2418-95-3Formula: C11H22N2O4)
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Formula: C11H22N2O4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics