Sheng, Yuwen; Chen, Yuwen; Zeng, Zhongqiu; Wu, Wenbi; Wang, Jing; Ma, Yuling; Lin, Yuan; Zhang, Jichao; Huang, Yulan; Li, Wenhua; Zhu, Qiyu; Wei, Xiao; Li, Suiyan; Wisanwattana, Wisanee; Li, Fu; Liu, Wanli; Suksamrarn, Apichart; Zhang, Guolin; Jiao, Wei; Wang, Fei published an article on January 13 ,2022. The article was titled 《Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming》, and you may find the article in Journal of Medicinal Chemistry.Synthetic Route of C11H22N2O4 The information in the text is summarized as follows:
Cancer cell proliferation in some organs often depends on conversion of pyruvate to oxaloacetate via pyruvate carboxylase (PC) for replenishing the tricarboxylic acid cycle to support biomass production In this study, PC was identified as the cellular target of erianin using the photoaffinity labeling-click chem.-based probe strategy. Erianin potently inhibited the enzymic activity of PC, which mediated the anticancer effect of erianin in human hepatocellular carcinoma (HCC). Erianin modulated cancer-related gene expression and induced changes in metabolic intermediates. Moreover, erianin promotes mitochondrial oxidative stress and inhibits glycolysis, leading to insufficient energy required for cell proliferation. Anal. of 14 natural analogs of erianin showed that some compounds exhibited potent inhibitory effects on PC. These results suggest that PC is a cellular target of erianin and reveal the unrecognized function of PC in HCC tumorigenesis; erianin along with its analogs warrants further development as a novel therapeutic strategy for the treatment of HCC. The results came from multiple reactions, including the reaction of H-Lys(Boc)-OH(cas: 2418-95-3Synthetic Route of C11H22N2O4)
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Synthetic Route of C11H22N2O4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics