In 2019,Chemistry – A European Journal included an article by Schwaerzer, Kuno; Bellan, Andreas; Zoeschg, Maximilian; Karaghiosoff, Konstantin; Knochel, Paul. Category: amides-buliding-blocks. The article was titled 《Magnesium Aldimines Prepared by Addition of Organomagnesium Halides to 2,4,6-Trichlorophenyl Isocyanide: Synthesis of 1,2-Dicarbonyl Derivatives》. The information in the text is summarized as follows:
The selective addition of organomagnesium reagents to 2,4,6-trichlorophenyl isocyanide leading to magnesiated aldimines I [R = n-Bu, Ph, Me2NC6H4, etc.] was reported. These aldimines reacted with Weinreb amides, ketones or carbonates to provide the corresponding carbonyl derivatives after acidic cleavage. This allowed for an efficient synthesis of 1,2-dicarbonyl compounds II [R1 = c-hexyl, Ph, 4-MeOC6H4, etc.] and α-hydroxy ketones III [R2R3 = (CH2)5, R2 = R3 = Ph, R2 = c-Pr, R3 = 4-FC6H4].N-Methoxy-N-methylacetamide(cas: 78191-00-1Category: amides-buliding-blocks) was used in this study.
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics