SDS of cas: 89281-13-0On May 20, 1999 ,《Design, synthesis and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors》 appeared in Journal of Medicinal Chemistry. The author of the article were Phillips, Gary; Davey, David D.; Eagen, Keith A.; Koovakkat, Sunil K.; Liang, Amy; Ng, Howard P.; Pinkerton, Michael; Trinh, Lan; Whitlow, Marc; Beatty, Alicia M.; Morrissey, Michael M.. The article conveys some information:
A novel series of 2,6-diphenoxypyridine derivatives I ( R = H, 3,5-Cl2, 4-CO3Et, etc.) and II (X = H, 3,5-Cl2) has been designed to inhibit factor Xa, a serine protease strategically located in the coagulation cascade. The evolution from the photochem. unstable bis(amidine) (Z,Z)-BABCH III to potent bis(amidine) compounds with a pyridine heterocycle as the core scaffold has been achieved. The most potent compound in the series, I (X = 3,5-F2-4-Me) (IV), has a Ki for human factor Xa of 12 nM. The selectivity of IV against bovine trypsin and human thrombin was greater than 90- and 1000-fold, resp. Two proposed modes of binding of IV to factor Xa are made based on the crystal structures of IV by itself and of IV bound to bovine trypsin. After reading the article, we found that the author used 2,6-Dichloroisonicotinamide(cas: 89281-13-0SDS of cas: 89281-13-0)
2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.SDS of cas: 89281-13-0
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics