《Engineering a Potent, Long-Acting, and Periphery-Restricted Oxytocin Receptor Agonist with Anorexigenic and Body Weight Reducing Effects》 was written by Pflimlin, Elsa; Zhou, Zhihong; Amso, Zaid; Fu, Qiangwei; Lee, Candy; Muppiddi, Avinash; Joseph, Sean B.; Nguyen-Tran, Van; Shen, Weijun. HPLC of Formula: 683-57-8 And the article was included in Journal of Medicinal Chemistry in 2020. The article conveys some information:
The effects of oxytocin on food intake and body weight reduction have been demonstrated in both animal models and human clin. studies. Despite being efficacious, oxytocin is enzymically unstable and thus considered to be unsuitable for long-term use in patients with obesity. Herein, a series of oxytocin derivatives were engineered through conjugation with fatty acid moieties that are known to exhibit high binding affinities to serum albumin. One analog (OT-12) in particular was shown to be a potent full agonist at the oxytocin receptor (OTR) in vitro with good selectivity and long half-life (24 h) in mice. Furthermore, OT-12 is peripherally restricted, with very limited brain exposure (1/190 of the plasma level). In a diet-induced obesity mouse model, daily s.c. administration of OT-12 exhibited more potent anorexigenic and body weight reducing effects than carbetocin. Thus, our results suggest that the long-acting, peripherally restricted OTR agonist may offer potential therapeutic benefits for obesity. After reading the article, we found that the author used 2-Bromoacetamide(cas: 683-57-8HPLC of Formula: 683-57-8)
2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.HPLC of Formula: 683-57-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics