Patel, Bhavesh H.; Mason, Andrew M.; Patel, Hetal; Coombes, R. Charles; Ali, Simak; Barrett, Anthony G. M. published their research in Journal of Organic Chemistry on August 5 ,2011. The article was titled 《Conversion of α-Amino Acids into Bioactive o-Aminoalkyl Resorcylates and Related Dihydroxyisoindolinones》.Formula: C13H26N2O4 The article contains the following contents:
The synthesis of biol. active o-aminoalkyl resorcylates and related dihydroxyisoindolinones, e.g. I, from functionalized α-amino acids without the use of phenolic protection is described. The key aminoalkyl-diketo-dioxinone intermediates were prepared utilizing a crossed Claisen condensation reaction in the presence of diethylzinc. The aromatic unit was constructed via late stage cyclization and aromatization, and subsequent modification provided the novel resorcylates which showed activity against a selection of receptors and kinases, including 5-HT and CDK.(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Formula: C13H26N2O4) was used in this study.
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Formula: C13H26N2O4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics