In 2019,Chemistry – A European Journal included an article by Moore, Lucas C.; Lo, Anna; Fell, Jason S.; Duong, Matthew R.; Moreno, Jose A.; Rich, Barry E.; Bravo, Martin; Fettinger, James C.; Souza, Lucas W.; Olmstead, Marilyn M.; Houk, Kendall N.; Shaw, Jared T.. Name: 4-Methylbenzenesulfonamide. The article was titled 《Acyclic Stereocontrol in the Additions of Nucleophilic Alkenes to α-Chiral N-Sulfonyl Imines》. The information in the text is summarized as follows:
Diastereoselective Lewis acid-mediated additions of nucleophilic alkenes R(R1)C=CH2 (R = H, Me, OTMS; R1 = Ph, CH2BF3K, CH2TMS) to N-sulfonyl imines (S,E)-R2CH(OR3)CH=NTs (R2 = Me, Ph, Bn; R3 = Me, Bn, TBDPS) are reported. The canonical polar Felkin-Anh model describing additions to carbonyls does not adequately describe analogous additions to N-sulfonyl imines. The development of conditions to produce both syn and anti products syn-R2CH(OR3)CH(NTs)CH2R4 [R4 = CH=CH2, C(O)Ph, CH2=CMe] with high diastereoselectivity and good yields has been described. A stereoelectronic model consistent with exptl. outcomes is also proposed. After reading the article, we found that the author used 4-Methylbenzenesulfonamide(cas: 70-55-3Name: 4-Methylbenzenesulfonamide)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: 4-Methylbenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics