In 1985,Journal of Medicinal Chemistry included an article by Martinez, Jean; Bali, Jean Pierre; Rodriguez, Marc; Castro, B.; Magous, R.; Laur, Jeanine; Lignon, Marie Francoise. Recommanded Product: 87694-50-6. The article was titled 《Synthesis and biological activities of some pseudo-peptide analogs of tetragastrin: the importance of the peptide backbone》. The information in the text is summarized as follows:
Title pseudo-peptide analogs I (Boc = Me3CO2C, R = H) (II), Boc-Trp-NHCH(CH2CHMe2)CH2-Asp-Phe-NH2 (III), and Boc-Trp-Leu-NHCH(CH2CO2H)CH2-Phe-NH2 (IV) were prepared by conventional solution methods. Thus, Boc-Trp-OH was condensed with MeONHMe.HCl by DCC to give Boc-TrpN(OMe)Me, which was reduced by LiAlH4 to give tryptophanal V. R1-Leu-Asp(OCH2Ph)-Phe-NH2 (VI, R1 = Boc) was prepared and then Boc-deblocked to give VI (R1 = H), which was treated with V in the presence of NaBH3CN to give I (R = CH2Ph), which was debenzylated by hydrogenolysis to give II. III was prepared similarly from Boc-Trp-NHCH(CH2CHMe2)CHO and H-Asp(OCH2Ph)-Phe-NH2, whereas PhCH2O2CNHCH(CH2CO2CMe3)CHO was prepared and used in the synthesis of IV. II and III have the same affinity as tetragastrin (VII) for gastrin receptor on isolated mucosal cells, whereas IV exhibited lower affinity. The acid secretion-stimulating activity of I in rats was identical to that of VII; III did not exhibit agonist activity but was able to antagonize the action of gastrin. In the experiment, the researchers used many compounds, for example, (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Recommanded Product: 87694-50-6)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Recommanded Product: 87694-50-6 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics