《Synthesis of 2-Aryl-2,3-dihydro-1,8-naphthyridin-4(1H)-ones by Deprotective Cyclization of N-{3-[(2E)-3-Arylprop-2-enoyl]pyridin-2-yl}-2,2-dimethylpropanamides in Water》 was published in Helvetica Chimica Acta in 2016. These research results belong to Kobayashi, Kazuhiro; Kosuna, Risa; Imaoka, Ayumi. Electric Literature of C10H14N2O The article mentions the following:
A new and convenient method for the preparation of 2-aryl-2,3-dihydro-1,8-naphthyridin-4(1H)-ones was developed. Thus, N-{3-[(2E)-3-arylprop-2-enoyl]pyridin-2-yl}-2,2-dimethylpropanamides were synthesized from com. available pyridin-2-amine using an easily performed three-step sequence and were subjected to cyclization with deprotection under acidic conditions in H2O to give the desired products. Similarly, 2-aryl-2,3-dihydro-1,7-naphthyridin-4(1H)-ones and 2-aryl-2,3-dihydro-1,6-naphthyridin-4(1H)-ones was prepared from pyridin-3-amine and pyridin-4-amine, resp. In the part of experimental materials, we found many familiar compounds, such as 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Electric Literature of C10H14N2O)
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Electric Literature of C10H14N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics