《Synthesis of 4-Aryl-1,7-naphthyridine-2(1H)-thiones by the Electrocyclic Reaction of 4-(1-Arylalk-1-enyl)-3-isothiocyanatopyridines Generated in situ from the Corresponding Isocyanides》 was written by Kobayashi, Kazuhiro; Kozuki, Taketoshi; Suzuki, Teruhiko. Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide And the article was included in Helvetica Chimica Acta on April 17 ,2012. The article conveys some information:
A convenient synthesis for 4-substituted and 3,4-disubstituted 1,7-naphthyridine-2(1H)-thiones has been developed. The method is based on the electrocyclic reaction of 4-(1-arylalk-1-enyl)-3-isothiocyanatopyridines, generated in situ by the treatment of the resp. isocyanides with S8 in the presence of a catalytic amount of selenium. The isocyanides can be easily prepared from com. available pyridin-3-amine by conventional organic reactions. In the experiment, the researchers used many compounds, for example, 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide)
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics