Kobayashi, Kazuhiro; Kozuki, Taketoshi; Konishi, Manami; Suzuki, Teruhiko; Tanmatsu, Miyuki; Konishi, Hisatoshi published an article in Helvetica Chimica Acta. The title of the article was 《Synthesis of 2,3-Diaryl-3H-pyrrolo[2,3-c]pyridin-3-ol Derivatives by the Reaction of Aryl(3-isocyanopyridin-4-yl)methanones with Aryl Grignard Reagents》.Application of 70298-88-3 The author mentioned the following in the article:
The reaction of aryl(3-isocyanopyridin-4-yl)methanones, e.g., I, easily prepared from com. available pyridin-3-amine, with aryl Grignard reagents gave, after aqueous workup, 2,3-diaryl-3H-pyrrolo[2,3-c]pyridin-3-ols. These rather unstable alcs. were O-acylated with Ac2O in pyridine in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP) to afford the corresponding 2,3-diaryl-3H-pyrrolo[2,3-c]pyridin-3-yl acetates, e.g., II, in relatively good yields. In the part of experimental materials, we found many familiar compounds, such as 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application of 70298-88-3)
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 70298-88-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics