Kaloudi, Aikaterini; Kanellopoulos, Panagiotis; Radolf, Thorsten; Chepurny, Oleg G.; Rouchota, Maritina; Loudos, George; Andreae, Fritz; Holz, George G.; Nock, Berthold Artur; Maina, Theodosia published their research in Molecular Pharmaceutics on August 3 ,2020. The article was titled 《[99mTc]Tc-DGA1, a Promising CCK2R-Antagonist-Based Tracer for Tumor Diagnosis with Single-Photon Emission Computed Tomography》.Reference of H-Lys(Boc)-OH The article contains the following contents:
Radiolabeled gastrin analogs have been proposed for theranostics of cholecystokinin subtype 2 receptor (CCK2R)-pos. cancer. Peptide radioligands based on other receptor antagonists have displayed superior pharmacokinetics and higher biosafety than agonists. Here, we present DGA1, a derivative of the nonpeptidic CCK2R antagonist Z-360 carrying an acyclic tetraamine, for [99mTc]Tc labeling. Preclin. comparison of [99mTc]Tc-DGA1 with [99mTc]Tc-DG2 (CCK2R-agonist reference) was conducted in HEK293-CCK2R/CCK2i4svR cells and mice models, qualifying [99mTc]Tc-DGA1 for further study in patients with CCK2R-pos. tumors and single-photon emission computed tomog./CT. In the experiment, the researchers used H-Lys(Boc)-OH(cas: 2418-95-3Reference of H-Lys(Boc)-OH)
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Reference of H-Lys(Boc)-OH
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