《Discovery of CyclicBoronic Acid QPX7728, an Ultrabroad-SpectrumInhibitor of Serine and Metallo-β-lactamases》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Hecker, Scott J.; Reddy, K. Raja; Lomovskaya, Olga; Griffith, David C.; Rubio-Aparicio, Debora; Nelson, Kirk; Tsivkovski, Ruslan; Sun, Dongxu; Sabet, Mojgan; Tarazi, Ziad; Parkinson, Jonathan; Totrov, Maxim; Boyer, Serge H.; Glinka, Tomasz W.; Pemberton, Orville A.; Chen, Yu; Dudley, Michael N.. Related Products of 683-57-8 The article mentions the following:
Despite major advances in the beta-lactamase inhibitor field, certain enzymes remain refractory to inhibition by agents recently introduced. Most important among these are the Class B (metallo) enzyme NDM-1 of Enterobacteriaceae and the Class D (OXA) enzymes of Acinetobacter baumannii. Continuing the boronic acid program that led to vaborbactam, efforts were directed toward expanding the spectrum to allow treatment of a wider range of organisms. Through key structural modifications of a bicyclic lead, stepwise gains in spectrum of inhibition were achieved, ultimately resulting in QPX7728, I. This compound displays a remarkably broad spectrum of inhibition, including Class B and Class D enzymes, and is little affected by porin modifications and efflux. I is a promising agent for use in combination with a beta-lactam antibiotic for the treatment of a wide range of multidrug resistant gram-neg. bacterial infections, by both i.v. and oral administration. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Related Products of 683-57-8)
2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Related Products of 683-57-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics