Estel, L.; Linard, F.; Marsais, F.; Godard, A.; Queguiner, G. published an article on February 28 ,1989. The article was titled 《Synthesis of ortho-substituted aminopyridines. Metalation of pivaloylamino derivatives》, and you may find the article in Journal of Heterocyclic Chemistry.Electric Literature of C10H14N2O The information in the text is summarized as follows:
The three isomeric (pivaloylamino)pyridines were lithiated and treated with various electrophiles to afford ortho-substituted pivaloylaminopyridines in good yields. Secondary pyridine alcs. were oxidized to the corresponding aminopyridyl ketones. Pyridopyrimidines, benzonaphthyridines, as well as an analog of the natural antitumor alkaloid ellipticine, were synthesized by this method. The experimental process involved the reaction of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Electric Literature of C10H14N2O)
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Electric Literature of C10H14N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics