Brandt, Florian; Ullrich, Martin; Laube, Markus; Kopka, Klaus; Bachmann, Michael; Loeser, Reik; Pietzsch, Jens; Pietzsch, Hans-Juergen; van den Hoff, Joerg; Wodtke, Robert published an article on January 13 ,2022. The article was titled 《”Clickable” albumin binders for modulating the tumor uptake of targeted radiopharmaceuticals》, and you may find the article in Journal of Medicinal Chemistry.Related Products of 2418-95-3 The information in the text is summarized as follows:
The intentional binding of radioligands to albumin gains increasing attention in the context of radiopharmaceutical cancer therapy as it can lead to an enhanced radioactivity uptake into the tumor lesions and, thus, to a potentially improved therapeutic outcome. However, the influence of the radioligand’s albumin-binding affinity on the time profile of tumor uptake has been only partly addressed so far. Based on the previously identified Nε-4-(4-iodophenyl)butanoyl-lysine scaffold, we designed “”clickable”” lysine-derived albumin binders (cLABs) and determined their dissociation constants toward albumin by novel assay methods. Structure-activity relationships were derived, and selected cLABs were applied for the modification of the somatostatin receptor subtype 2 ligand (Tyr3)octreotate. These novel conjugates were radiolabeled with copper-64 and subjected to a detailed in vitro and in vivo radiopharmacol. characterization. Overall, the results of this study provide an incentive for further investigations of albumin binders for applications in endoradionuclide therapies. The experimental process involved the reaction of H-Lys(Boc)-OH(cas: 2418-95-3Related Products of 2418-95-3)
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. These amino acids may be present in low concentrations and play a vital part as an intermediate in a biosynthetic pathway, e.g., ornithine, homoserine, or cystathionine. In contrast they may act as a major storage form of nitrogen, e.g., canavanine in the seed of Canavalia ensiformis, or may be formed in high amounts in response to an external stress, e.g., γ-aminobutyrate.Related Products of 2418-95-3 It is possible that some of these nonprotein amino acids may serve as insecticidal or fungicidal agents.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics