McAtee, Rory C.; Noten, Efrey A.; Stephenson, Corey R. J. published the artcile< Arene dearomatization through a catalytic N-centered radical cascade reaction>, Name: 3-Fluorobenzenesulfonamide, the main research area is cyclohexadiene fused sultam diastereoselective preparation; arylsulfonamide arene dearomatization iridium catalyzed centered radical cascade.
Herein, a catalytic protocol was reported to initiate a carboamination/dearomatization cascade that proceeded through transient sulfonamidyl radical intermediates formed from native sulfonamide N-H bonds leading to 1,4-cyclohexadiene-fused sultams such as I [R1 = F, CN, CF3, etc.; R2 = H, F; R3 = R4 = Me; R3R4 = (CH2)3; R5 = H, Me; X = CH2, O]. Importantly, this work demonstrated a facile approach to employ two-dimensional aromatic compounds as modular building blocks to generate richly substituted, three-dimensional compounds These reactions occurred at room temperature under visible light irradiation and were catalyzed by the combination of an iridium(III) photocatalyst and a dialkyl phosphate base. Reaction optimization, substrate scope, mechanistic features and synthetic applications of this transformation were presented.
Nature Communications published new progress about Amination catalysts. 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Name: 3-Fluorobenzenesulfonamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics