Zhao, Yichao; Bruce, Lachlan David; Jin, Jianwen; Xia, Bo; Chan, Philip Wai Hong published the artcile< Copper catalyzed N-formylation of α-silyl-substituted tertiary N-alkylamines by air>, HPLC of Formula: 6280-57-5, the main research area is dialkylaminomethyl trimethylsilane copper catalyst formylation; dialkyl formylamine preparation.
A site-selective method to prepare N-formyl amines efficiently that relies on the copper(I)-catalyzed oxidation of α-silyl-substituted tertiary N-alkylamines by air at room temperature was described. The oxidative protocol was shown to exhibited excellent functional group tolerance as it was applicable to a wide variety of amine substrates and a number of bioactive mols. and natural products. Moreover, it delinates a ligand- and additive-free amine oxidation process mediated by a low-cost metal salt with oxygen from air taking on the role of both the terminal oxidant and as part of the formylation reagent, which was unprecedented in copper catalysis. It also offered the first synthetic method that can selectively generate α-amino radical species as reactive intermediates from α-silylamines under non-photochem. reaction conditions.
Green Chemistry published new progress about Formamides Role: SPN (Synthetic Preparation), PREP (Preparation) (N,N-dialkyl). 6280-57-5 belongs to class amides-buliding-blocks, and the molecular formula is C17H35NO, HPLC of Formula: 6280-57-5.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics