The author of 《Nickel-Catalyzed Carbofluoroalkylation of 1,3-Enynes to Access Structurally Diverse Fluoroalkylated Allenes》 were Zhang, Kai-Fan; Bian, Kang-Jie; Li, Chao; Sheng, Jie; Li, Yan; Wang, Xi-Sheng. And the article was published in Angewandte Chemie, International Edition in 2019. Safety of N-Methoxy-N-methylacetamide The author mentioned the following in the article:
A nickel-catalyzed 1,4-carbofluoroalkylation of 1,3-enynes R1CCC(R2)=CH2 [R1 = H, heptyl, cyclohexyl, Ph, thiophen-3-yl, etc.; R2 = Me, H, Ph, (CH2)2OC(O)CH3] to access structurally diverse fluoroalkylated allenes R3C(R1)=C=C(R2)CH2R4 [R3 = Ph, naphthalen-2-yl, 2-methylphenyl, etc.; R4 = CF2C(O)OCH2CH3, CF3, CF2C6H5, etc.;] has been established. This method has demonstrated high catalytic reactivity, mild reaction conditions, broad substrate scope, and excellent functional-group tolerance. The key to success is the use of a nickel catalyst to generate different fluoroalkyl radicals from readily available and structurally diverse fluoroalkyl halides R4X (X = Br, I) to access 1,4-difunctionalization of 1,3-enynes by a radical relay. This strategy provides facile synthesis of structurally diverse multisubstituted allenes, and offers a solution for batch production of various fluorinated bioactive mols. for drug discovery by further transformations. After reading the article, we found that the author used N-Methoxy-N-methylacetamide(cas: 78191-00-1Safety of N-Methoxy-N-methylacetamide)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Safety of N-Methoxy-N-methylacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics