SDS of cas: 70-55-3In 2020 ,《Electrically-driven N(sp2)-C(sp2/3) bond cleavage of sulfonamides》 was published in ACS Sustainable Chemistry & Engineering. The article was written by Wetzel, Annica; Jones, Alan M.. The article contains the following contents:
The discovery and development of an unexpected elec.-driven N(sp2)-C(sp3) and N(sp2)-C(sp2) bond cleavage reaction alongside dehydrogenative C-O bond coupling reactions both in batch and flow conditions was reported. Intramol. trapping experiments with the diuretic hydrochlorothiazide, gave insight into the intermediacy of an N-sulfonyliminium ion en route to the related drug, chlorothiazide. Using only electrons as the oxidant, this was a green and sustainable technol. advance for sulfonamide deprotection chem. and drug metabolism studies.4-Methylbenzenesulfonamide(cas: 70-55-3SDS of cas: 70-55-3) was used in this study.
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.SDS of cas: 70-55-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics