Application of 683-57-8In 2020 ,《Chemical synthesis of an enzyme containing an artificial catalytic apparatus》 was published in Australian Journal of Chemistry. The article was written by Torbeev, Vladimir; Kent, Stephen B. H.. The article contains the following contents:
With the goal of investigating electronic aspects of the catalysis of peptide bond hydrolysis, an analog of HIV-1 protease was designed in which a non-peptide hydroxy-isoquinolinone artificial catalytic apparatus replaced the conserved Asp25-Thr26-Gly27 sequence in each 99-residue polypeptide chain of the homodimeric enzyme mol. The enzyme analog was prepared by total chem. synthesis and had detectable catalytic activity on known HIV-1 protease peptide substrates. Compared with uncatalyzed hydrolysis, the analog enzyme increased the rate of peptide bond hydrolysis by ∼108-fold. Extensions of this unique approach to the study of enzyme catalysis in HIV-1 protease are discussed. In the experiment, the researchers used 2-Bromoacetamide(cas: 683-57-8Application of 683-57-8)
2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Application of 683-57-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics