Tao, Ming; Bihovsky, Ron; Kauer, James C. published their research in Bioorganic & Medicinal Chemistry Letters on December 17 ,1996. The article was titled 《Inhibition of calpain by peptidyl heterocycles》.Product Details of 87694-50-6 The article contains the following contents:
Dipeptidyl and tripeptidyl heterocycles designed to mimic peptide ketoamides and ketoacids were prepared and evaluated in vitro as inhibitors of human calpain I. For example, Boc-Leu-Leu-imidazole, I, inhibited calpain I at low micromolar concentrations In the part of experimental materials, we found many familiar compounds, such as (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Product Details of 87694-50-6)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Product Details of 87694-50-6 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics