《DOTA-Branched Organic Frameworks as Giant and Potent Metal Chelators》 was published in Journal of the American Chemical Society in 2020. These research results belong to Sun, Chengjie; Lin, Hongyu; Gong, Xuanqing; Yang, Zhaoxuan; Mo, Yan; Chen, Xiaoyuan; Gao, Jinhao. COA of Formula: C2H4BrNO The article mentions the following:
Multinuclear complexes as metallo-agents for clin. use have caught extensive attention. In this paper, using 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) as both a functioning unit and a constructing junction, the authors build a series of DOTA-branched organic frameworks with multiple chelating holes by organizing DOTA layer by layer. These giant chelators are well characterized, which reveals their nanosized and soft structures. Further experiments demonstrate that they could efficiently hold abundant metal ions with much higher kinetic stabilities than the conventional small DOTA chelator. Their corresponding polynuclear complexes containing Gd3+, Tb3+, or both show superior imaging properties, excellent feasibility for peripheral modification, and unusual kinetic stability. This work can be easily extended to the fabrication of diverse homomultinuclear complexes and core/shell heteromultinuclear complexes with multifunctional properties. The authors expect that this new type of giant mols. and the ligand-branching strategy would open up a new avenue for the design and construction of next-generation polymetallic agents with high performance and stabilities for biomedical applications. In the experiment, the researchers used 2-Bromoacetamide(cas: 683-57-8COA of Formula: C2H4BrNO)
2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.COA of Formula: C2H4BrNO
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics