Related Products of 87694-50-6On March 4, 2020, Schwartz, Brett D.; Zhang, Meng Yao; Attard, Riley H.; Gardiner, Michael G.; Malins, Lara R. published an article in Chemistry – A European Journal. The article was 《Structurally Diverse Acyl Bicyclobutanes: Valuable Strained Electrophiles》. The article mentions the following:
This work reported two efficient pathways for the rapid preparation of over 20 structurally diverse bicyclo[1.1.0]butane (BCB) ketones, such as I [R = cuban-1-yl, BOCHNCH2, 4-MeOC6H4, etc.] encompassing simple alkyl and aryl derivatives, as well as unprecedented amino acid, dipeptide, bioisostere, and bifunctional linchpin reagents currently inaccessible using literature methods. Analogs were readily forged in two steps and in high yields from simple carboxylic acids or through unsym. ketone synthesis beginning with a convenient carbonyl dication equivalent The utility of this novel toolbox of strained electrophiles for selective modification of proteinogenic nucleophiles was highlighted. The results came from multiple reactions, including the reaction of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Related Products of 87694-50-6)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Related Products of 87694-50-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics