Ren, Zhiqiang; Sun, Zhongliu; Li, Yifei; Fan, Xin; Dai, Mingda; Wang, Yunxia; Hu, Xiangdong published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Total Synthesis of (+)-3-Deoxyfortalpinoid F, (+)-Fortalpinoid A, and (+)-Cephinoid H》.Category: amides-buliding-blocks The article contains the following contents:
3-Deoxyfortalpinoid F, fortalpinoid A, and cephinoid H are members of the Cephalotaxus diterpenoids class of natural products, which feature diverse chem. structures and valuable biol. activities. We report herein the development of a diastereoselective Pauson-Khand reaction as an effective pathway to access the core tetracyclic skeleton, which is found widely in Cephalotaxus diterpenoids. Furthermore, we enabled the construction of the tropone moiety through a ring-closing metathesis/elimination protocol. Based on the developed strategy, asym. synthesis of the title compounds has been achieved for the first time. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Category: amides-buliding-blocks)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics