Pehere, Ashok D.; Nguyen, Steven; Garlick, Sarah K.; Wilson, Danny W.; Hudson, Irene; Sykes, Matthew J.; Morton, James D.; Abell, Andrew D. published an article on January 15 ,2019. The article was titled 《Tripeptide analogues of MG132 as protease inhibitors》, and you may find the article in Bioorganic & Medicinal Chemistry.Synthetic Route of C13H26N2O4 The information in the text is summarized as follows:
The 26S proteasome and calpain are linked to a number of important human diseases. Here, we report a series of analogs of the prototypical tripeptide aldehyde inhibitor MG132 that show a unique combination of high activity and selectivity for calpains over proteasome. Tripeptide aldehydes (1-3) with an aromatic P3 substituent show enhanced activity and selectivity against ovine calpain 2 relative to chymotrypsin-like activity of proteasome. Docking studies reveal the key contacts between inhibitors and calpain to confirm the importance of the S3 pocket with respect to selectivity between calpains 1 and 2 and the proteasome.(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Synthetic Route of C13H26N2O4) was used in this study.
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.Synthetic Route of C13H26N2O4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics