Okada, Yoshio; Taguchi, Hiroaki; Yokoi, Toshio published their research in Chemical & Pharmaceutical Bulletin on December 31 ,1996. The article was titled 《Amino acids and peptides. XLVII. Facile synthesis of flavacol, deoxymuta-aspergillic acid and optically active deoxyaspergillic acid from dipeptidyl aldehydes》.HPLC of Formula: 87694-50-6 The article contains the following contents:
2(1H)-pyrazinone ring-containing natural products, flavacol, deoxymuta-aspergillic acid and optically active deoxyaspergillic acid, were easily synthesized by a newly developed procedure for preparation of 2(1H)-pyrazinone derivatives from dipeptidyl substrates BocNHCH(R2)CONHCH(R1)CON(Me)OMe (R1 = iso-Bu, iso-Pr, sec-Bu(S), sec-Bu(R); R2 = Bzl, iso-Bu). The absolute configuration of natural deoxyaspergillic acid was synthetically determined as S. After reading the article, we found that the author used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6HPLC of Formula: 87694-50-6)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.HPLC of Formula: 87694-50-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics