《[Tyrosine kinase inhibitor–hematological malignancies].》 was published in Gan to kagaku ryoho. Cancer & chemotherapy in 2001. These research results belong to Ohno, R. Application In Synthesis of 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide The article mentions the following:
STI571 selectively inhibits the ABL-tyrosine kinase, the activity of which is activated by the formation of chimeric BCR/ABL. A phase I study in the USA showed STI571 to be remarkably effective in cases of interferon-refractory chronic myeloid leukemia, with almost no adverse effects. STI571 may become the first choice drug prior to stem cell transplantation and interferon treatment. The experimental process involved the reaction of 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7Application In Synthesis of 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide)
2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Application In Synthesis of 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics