Nishad, Chandra Shekhar; Haldar, Krishna Kanta; Banerjee, Biplab published the artcile< Metal-Free Direct Access to N-Sulfonyl Amidines from Sulfonamides and Secondary Amines Involving Tandem C-N Bond Formations>, Recommanded Product: 3-Fluorobenzenesulfonamide, the main research area is sulfonyl amidine preparation metal free one pot; sulfonamide secondary amine tandem carbon nitrogen bond formation.
Authors report a mild and efficient metal-free one-pot procedure for the synthesis of N-sulfonyl amidines via the direct reaction of sulfonamides with secondary amines without using any additives. A wide range of substrates with variety of functional groups is well tolerated under the reaction conditions. Preliminary mechanistic studies indicate that the secondary amine plays a dual role as a C1 source of the amidine group and an aminating agent. Synthetic utility of this method is shown in the late-stage functionalization of drug mols. on the gram scale.
Journal of Organic Chemistry published new progress about Alicyclic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1524-40-9 belongs to class amides-buliding-blocks, and the molecular formula is C6H6FNO2S, Recommanded Product: 3-Fluorobenzenesulfonamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics