Miletin, Miroslav; Dolezal, Martin; Opletalova, Veronika; Hartl, Jiri; Kral’ova, Katarina; Machacek, Milos published an article in Molecules [online computer file]. The title of the article was 《Some anilides of 2-alkylthio- and 2-chloro-6-alkylthio-4-pyridinecarboxylic acids: synthesis and photosynthesis-inhibiting activity》.Computed Properties of C6H4Cl2N2O The author mentioned the following in the article:
Many compounds containing a -CONH- group display photosynthesis-inhibiting activity. Based on this structural feature, a group of anilides of 2-alkylthio- (I) or 2-chloro-6-alkylthio-4-pyridinecarboxylic acids (II) was synthesized. The prepared compounds were tested for their inhibition of the oxygen evolution rate (OER) in spinach chloroplasts. A quasi-parabolic dependence between photosynthesis-inhibiting activity and the lipophilicity of the compounds was determined The inhibitory activity of compounds I was higher than that of II for comparable lipophilicity values. The results came from multiple reactions, including the reaction of 2,6-Dichloroisonicotinamide(cas: 89281-13-0Computed Properties of C6H4Cl2N2O)
2,6-Dichloroisonicotinamide(cas: 89281-13-0) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Computed Properties of C6H4Cl2N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics