The author of 《Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids》 were Mamontov, Alexander; Martin-Mingot, Agnes; Metayer, Benoit; Karam, Omar; Zunino, Fabien; Bouazza, Fodil; Thibaudeau, Sebastien. And the article was published in Chemistry – A European Journal in 2020. Reference of N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide The author mentioned the following in the article:
Site-selective functionalization of arenes that was complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2-H bonds of aromatic amines occurred. Furthermore, the superacid-promoted (poly)protonation of the mols. acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients. In the part of experimental materials, we found many familiar compounds, such as N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0Reference of N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide)
N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Reference of N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics