Knauer, Sascha; Koch, Niklas; Uth, Christina; Meusinger, Reinhard; Avrutina, Olga; Kolmar, Harald published an article in Angewandte Chemie, International Edition. The title of the article was 《Sustainable peptide synthesis enabled by a transient protecting group》.HPLC of Formula: 2418-95-3 The author mentioned the following in the article:
The growing interest in synthetic peptides has prompted the development of viable methods for their sustainable production Currently, large amounts of toxic solvents are required for peptide assembly from protected building blocks, and switching to water as a reaction medium remains a major hurdle in peptide chem. We report an aqueous solid-phase peptide synthesis strategy that is based on a water-compatible 2,7-disulfo-9-fluorenylmethoxycarbonyl (Smoc) protecting group. This approach enables peptide assembly under aqueous conditions, real-time monitoring of building block coupling, and efficient postsynthetic purification The procedure for the synthesis of all natural and several non-natural Smoc-protected amino acids is described, as well as the assembly of 22 peptide sequences and the fundamental issues of SPPS, including the protecting group strategy, coupling and cleavage efficiency, stability under aqueous conditions, and crucial side reactions. In the experiment, the researchers used H-Lys(Boc)-OH(cas: 2418-95-3HPLC of Formula: 2418-95-3)
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).HPLC of Formula: 2418-95-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics