Jin, Lianwen; Zeng, Xiaoli; Li, Siyang; Qiu, Guofu; Liu, Peng published an article in European Journal of Organic Chemistry. The title of the article was 《Copper-Catalyzed Regioselective Halogenation of Anilides with N-Fluorobenzenesulfonimide》.Category: amides-buliding-blocks The author mentioned the following in the article:
Here described a copper-catalyzed direct chlorination and bromination of anilides in the presence of N-fluorobenzenesulfonimide as oxidant. This protocol shows excellent regioselectivity and mono-substitution with inexpensive KCl or NaBr as the halogen source and industrially friendly solvent. In addition to this study using N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide, there are many other studies that have used N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0Category: amides-buliding-blocks) was used in this study.
N-(2-Chloro-4-(trifluoromethyl)phenyl)acetamide(cas: 247170-19-0) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics