Product Details of 4746-61-6On October 30, 2014 ,《Synthesis and cytotoxicity of thieno[2,3-b]pyridine and furo[2,3-b]pyridine derivatives》 was published in European Journal of Medicinal Chemistry. The article was written by Hung, Joy M.; Arabshahi, Homayon J.; Leung, Euphemia; Reynisson, Johannes; Barker, David. The article contains the following contents:
Forty seven thieno[2,3-b]pyridine-2-carboxamides, furo[2,3-b]pyridine-2-carboxamides, tetrahydrothieno[2,3-b]quinolone-2-carboxamides and their derivatives were synthesized and tested for their antiproliferative activity against the NCI-60 cell lines. The tetrahydrothieno[2,3-b]quinolone-2-carboxamides I (R = Ph, 4-MeOC6H4, 3-BrC6H4, 3,5-Cl2C6H3, etc.) were found to have the greatest activity, with the compound I (R = 3-MeOC6H4) being the most active, with GI50 values in the low nanomolar range against a range of cell lines, in particular the melanoma cell line MDA-MD-435 (GI50 – 23 nM) and the breast cancer cell line MDA-MB-468 (GI50 – 46 nM). Mol. modeling of series I against phosphoinositide specific-phospholipase C revealed that the side chains of the amino acids His356, Glu341, Arg549 and Lys438 are involved in hydrogen bonding with the ligands as well as a lipophilic pocket is occupied by the Ph carboxamide moiety. After reading the article, we found that the author used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Product Details of 4746-61-6)
2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Product Details of 4746-61-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics