《L-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of L-histidine and L-tryptophan》 was written by Hall, Colton; Wolfe, Hannah; Wells, Alyssa; Chien, Huan-Chieh; Colas, Claire; Schlessinger, Avner; Giacomini, Kathleen M.; Thomas, Allen A.. HPLC of Formula: 71432-55-8This research focused ontriazole preparation cell uptake LAT1 inhibitor antitumor agent; Click chem Huisgen cycloaddition brain disorder; membrane transporter triazole histidine tryptophan; Amino acid; Blood-brain barrier; Cancer; Click chemistry; Membrane transporter; Solute carrier family; Triazole. The article conveys some information:
A series of 1,2,3-triazole analogs of the amino acids L-histidine and L-tryptophan were modeled, synthesized and tested for L-type amino acid transporter 1 (LAT1; SLC7A5) activity to guide the design of amino acid-drug conjugates (prodrugs). These triazoles were conveniently prepared by the highly convergent Huisgen 1,3-dipolar cycloaddition (Click Chem.). Despite comparable predicted binding modes, triazoles generally demonstrated reduced cell uptake and LAT1 binding potency relative to their natural amino acid counterparts. The structure-activity relationship (SAR) data for these triazoles has important ramifications for treating cancer and brain disorders using amino acid prodrugs or LAT1 inhibitors. In the experiment, the researchers used tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8HPLC of Formula: 71432-55-8)
tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).HPLC of Formula: 71432-55-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics