Gonnet, Lori; Lennox, Cameron B.; Do, Jean-Louis; Malvestiti, Ivani; Koenig, Stefan G.; Nagapudi, Karthik; Friscic, Tomislav published the artcile< Metal-Catalyzed Organic Reactions by Resonant Acoustic Mixing>, Application of C10H13ClN2O3S, the main research area is tolbutamide preparation antidiabetic; Acoustic Mixing; Catalysis; Green Chemistry; Mechanochemistry; Pharmaceuticals.
Catalytic organic synthesis by resonant acoustic mixing (RAM), a mechanochem. methodol. that does not require bulk solvent or milling media. Using as model reactions ruthenium-catalyzed ring-closing metathesis and copper-catalyzed sulfonamide-isocyanate coupling, RAM mechanosynthesis was shown to be faster, operationally simpler than conventional ball-milling, while also provided the first example of a mechanochem. strategy for ruthenium-catalyzed ene-yne metathesis. Reactions by RAM were readily and directly scaled-up without any significant changes in reaction conditions, as shown by the straightforward 200-fold scaling-up of the synthesis of the antidiabetic drug Tolbutamide, from hundreds of milligrams directly to 30 g.
Angewandte Chemie, International Edition published new progress about Antidiabetic agents. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Application of C10H13ClN2O3S.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics