Fulo, Harvey F.; Rueb, Nicole J.; Gaston, Robert Jr.; Batsomboon, Paratchata; Ahmed, Kh Tanvir; Barrios, Amy M.; Dudley, Gregory B. published an article in 2021. The article was titled 《Synthesis of illudalic acid and analogous phosphatase inhibitors》, and you may find the article in Organic & Biomolecular Chemistry.SDS of cas: 78191-00-1 The information in the text is summarized as follows:
Here authors validate a two-step process-convergent [4+2] benzannulation and one-pot coordinated functional group manipulations-for preparing the key trifunctional pharmacophore of illudalic acid. The modular building blocks are readily available in 2-3 steps, for a longest linear sequence (LLS) of 5 steps to illudalic acid from 3,3-dimethylcyclopentanone. A small collection of analogous indanes and tetralins featuring the same pharmacophore were prepared by a similar route. These compounds potently and selectively inhibit the human leukocyte common antigen-related (LAR) subfamily of protein tyrosine phosphatases (PTPs). Evidence supporting a postulated covalent ligation mechanism is provided herein. In addition to this study using N-Methoxy-N-methylacetamide, there are many other studies that have used N-Methoxy-N-methylacetamide(cas: 78191-00-1SDS of cas: 78191-00-1) was used in this study.
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.SDS of cas: 78191-00-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics