Fiakpui, Charles Y.; Knaus, Edward E. published an article in Canadian Journal of Chemistry. The title of the article was 《An improved synthesis of 1,3-dihydro-1-methyl-5-phenyl-2H-pyrido[3,4-e]-1,4-diazepin-2-one via ortho-directed lithiation of 3-[(tert-butylcarbonyl)- and 3-[(tert-butoxycarbonyl)amino)pyridine]》.Formula: C10H14N2O The author mentioned the following in the article:
The ortho-directed lithiation of the title compounds I (R = CMe3, OCMe3) with alkyllithiums and benzoylation with PhCONEt2 followed by acid hydrolysis gave 63-66% 3-amino-4-benzoylpyridine (II). Amidation of R1NHCH2CO2H (R1 = PhCH2O2C, Me3CO2C) with II afforded[[(aminomethyl)carbonyl]amino]benzoylpyridines III (same R1). Acid-catalyzed hydrolysis and cyclocondensation of III, followed by methylation gave pyridodiazepinone IV in 36% overall yield from I.2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Formula: C10H14N2O) was used in this study.
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Formula: C10H14N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics