The author of 《Synthesis and evaluation of new protein-tyrosine kinase inhibitors. Part 1. Pyridine-containing stilbenes and amides》 were Cushman, Mark; Nagarathnam, Dhanapalan; Gopal, D.; Geahlen, Robert L.. And the article was published in Bioorganic & Medicinal Chemistry Letters in 1991. Related Products of 64479-78-3 The author mentioned the following in the article:
A series of pyridine-containing stilbene and amide derivatives based on the structure of piceatannol, a naturally occurring protein-tyrosine kinase inhibitor, were prepared and tested for inhibition of p56lck. The most potent of these compounds (I) is a competitive inhibitor of p56lck with respect to ATO. The experimental part of the paper was very detailed, including the reaction process of N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Related Products of 64479-78-3)
N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Related Products of 64479-78-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics